Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GUCY1B2 | O75343 | 5/20 | 0.37 |
| ▸ | GUCY1A2 | P33402 | 5/20 | 0.37 |
| ▸ | GUCY1A1 | Q02108 | 5/20 | 0.37 |
| ▸ | GUCY1B1 | Q02153 | 5/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014461 | 0.90 | AR (0.52) | ARRAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL3013290 | 0.90 | AR (0.51) | ARRAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL3019682 | 0.89 | SMN1; SMN2 (0.52) | RAB9ASMN1; SMN2NPC1MAPTMEN1 | |
| SCHEMBL3021480 | 0.88 | SMN1; SMN2 (0.41) | ARRAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL3016088 | 0.87 | AR (0.40) | ARRAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL3010712 | 0.87 | SMN1; SMN2 (0.47) | RAB9ASMN1; SMN2NPC1MAPTMEN1 | |
| SCHEMBL3010963 | 0.87 | AR (0.46) | ARRAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL3020871 | 0.87 | SMN1; SMN2 (0.46) | ARRAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL3017344 | 0.86 | SMN1; SMN2 (0.44) | RAB9ASMN1; SMN2NPC1MAPTMEN1 | |
| SCHEMBL3020819 | 0.86 | SMN1; SMN2 (0.43) | ARRAB9ASMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722681-B2 | N-sulfonyl thiazolylpiperazine derivatives and related N-sulfonyl heterocyclic derivatives for the treatment of neuro degenerative diseases | NV REMYND (BE) | 2014-05-13 | — | — | US | disclosed |
| US-20100197703-A1 | N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197703-A1 | N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | SMN1; SMN2, HTT, SNCA | AR 3801/4885RAB9A 2943/4885SMN1; SMN2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.