Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 17/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24880543 | 1.00 | CRBN (0.44) | CRBNDDB1POLBSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL30112461 | 0.99 | CRBN (0.43) | CRBNDDB1POLBSLC6A2SLC6A4 | |
| SCHEMBL24319255 | 0.84 | CRBN (0.47) | CRBNDDB1POLB | |
| SCHEMBL24124611 | 0.84 | CRBN (0.53) | CRBNDDB1POLB | |
| SCHEMBL29977325 | 0.84 | CRBN (0.53) | CRBNDDB1POLB | |
| Hydrochloric Acid SCHEMBL29094538 | 0.83 | CRBN (0.52) | CRBNDDB1POLB | |
| Hydrochloric Acid SCHEMBL29877315 | 0.83 | CRBN (0.52) | CRBNDDB1POLB | |
| SCHEMBL31612890 | 0.81 | APP (0.45) | CRBNDDB1 | |
| SCHEMBL24881051 | 0.81 | CRBN (0.41) | CRBNDDB1POLB | |
| SCHEMBL31639672 | 0.81 | CRBN (0.51) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367113-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | Biogen MA Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| CN-117940414-A | Compounds for targeting IRAK4 protein degradation | 渤健马萨诸塞州股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| WO-2023283610-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | BIOGEN MA INC. (US) | 2023-01-12 | — | — | WO | disclosed |