Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 18/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | RGS12 | O14924 | 1/20 | 0.51 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.51 |
| ▸ | PDE6D | O43924 | 1/20 | 0.51 |
| ▸ | PDE8A | O60658 | 1/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30112978 | 1.00 | SLC29A1 (0.57) | SLC29A1KDM4EMEN1PDE2ARGS12 | |
| SCHEMBL30112967 | 1.00 | SLC29A1 (0.57) | SLC29A1KDM4EMEN1PDE2ARGS12 | |
| SCHEMBL25205562 | 0.94 | SLC29A1 (0.63) | SLC29A1KDM4EMEN1PDE2ARGS12 | |
| SCHEMBL30113046 | 0.94 | SLC29A1 (0.63) | SLC29A1KDM4EMEN1PDE2ARGS12 | |
| SCHEMBL25214099 | 0.94 | SLC29A1 (0.63) | SLC29A1KDM4EMEN1PDE2ARGS12 | |
| SCHEMBL30113096 | 0.94 | SLC29A1 (0.63) | SLC29A1KDM4EMEN1PDE2ARGS12 | |
| SCHEMBL30112941 | 0.90 | SLC29A1 (0.53) | SLC29A1KDM4EMEN1PDE2ARGS12 | |
| SCHEMBL30113026 | 0.90 | SLC29A1 (0.53) | SLC29A1KDM4EMEN1PDE2ARGS12 | |
| SCHEMBL25489001 | 0.89 | SLC29A1 (0.57) | SLC29A1KDM4EMEN1PDE2ARGS12 | |
| SCHEMBL25488997 | 0.89 | SLC29A1 (0.57) | SLC29A1KDM4EMEN1PDE2ARGS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110784-A1 | PYRIMIDO[5,4-D]PYRIMIDINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS | iTeos Belgium SA (BE) | 2023-01-04 | — | — | EP | claimed |