Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.49 |
| ▸ | YAP1 | P46937 | 1/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 4/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24879995 | 1.00 | TEAD1 (0.49) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL30114253 | 0.91 | TEAD1 (0.49) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24879998 | 0.91 | TEAD1 (0.49) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24879997 | 0.91 | TEAD1 (0.49) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24879999 | 0.90 | TEAD1 (0.49) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL28961313 | 0.89 | TEAD1 (0.47) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL30114343 | 0.89 | TEAD1 (0.47) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24879778 | 0.86 | TEAD1 (0.47) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL30114629 | 0.86 | TEAD1 (0.47) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24879863 | 0.84 | TEAD1 (0.51) | TEAD1YAP1TNNI3KMAPTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115594680-A | TEAD inhibitor | 武汉人福创新药物研发中心有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |