SCHEMBL30114909

SCHEMBL30114909

C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(Cl)cc1F)c1ccc(C(=O)O)cc1

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 20/20 0.82
PTGER2 P43116 6/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2352718 1.00 PTGER4 (0.82) PTGER4PTGER2
SCHEMBL2352091 0.93 PTGER4 (0.84) PTGER4PTGER2
SCHEMBL30114833 0.93 PTGER4 (0.84) PTGER4PTGER2
SCHEMBL5359022 0.90 PTGER4 (0.82) PTGER4PTGER2
SCHEMBL5358103 0.89 PTGER4 (0.77) PTGER4PTGER2
SCHEMBL5366979 0.89 PTGER4 (0.83) PTGER4PTGER2
SCHEMBL1284486 0.89 PTGER4 (0.86) PTGER4PTGER2
SCHEMBL19713696 0.89 PTGER4 (0.86) PTGER4PTGER2
SCHEMBL5365775 0.88 PTGER4 (0.65) PTGER4PTGER2
SCHEMBL30114920 0.88 PTGER4 (0.81) PTGER4PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2976105-B1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC (JP) 2023-01-04 EP disclosed