Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300991 | 0.92 | PIK3CD (0.62) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL293199 | 0.89 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL301171 | 0.88 | PIK3CD (0.75) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL300978 | 0.87 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL301307 | 0.87 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL29793901 | 0.87 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL30662742 | 0.87 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL300821 | 0.87 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL301173 | 0.87 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL301340 | 0.85 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679432-B | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | SIGNAL PHARM LLC | 2015-04-22 | — | — | CN | claimed |
| EP-2078018-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2012-03-14 | — | — | EP | claimed |
| CN-107976546-B | Inhibition of phosphorylation of TOR kinase inhibitory Activity markers PRAS40, GSK 3-beta, or P70S6K1 | 西格诺药品有限公司 | 2020-10-27 | — | — | CN | disclosed |
| CN-110721186-A | Treatment of prostate cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2020-01-24 | — | — | CN | disclosed |
| CN-107157990-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2020-01-07 | — | — | CN | disclosed |
| CN-109846884-A | With TOR kinase inhibitor for treating cancer | 西格诺药品有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-105039520-A | Identification of gene expression profile as a predictive biomarker for lkb1 status | SIGNAL PHARM LLC | 2015-11-11 | — | — | CN | disclosed |
| CN-101679432-B | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | SIGNAL PHARM LLC | 2015-04-22 | — | — | CN | disclosed |
| CN-104271139-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-104271138-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-103857804-A | Identification of gene expression profiles as predictive biomarkers for LKB1 status | SIGNAL PHARM LLC | 2014-06-11 | — | — | CN | disclosed |
| CN-102821767-A | IDENTIFICATION OF LKB1 MUTATION AS A PREDICTIVE BIOMARKER FOR SENSITIVITY TO TOR KINASE INHIBITORS | SIGNAL PHARM LLC | 2012-12-12 | — | — | CN | disclosed |
| CN-101679432-A | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | SIGNAL PHARM LLC | 2010-03-24 | — | — | CN | disclosed |