Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782423 | 0.88 | ATM (0.54) | ATMKDM4EGSK3BHPGDMAPK1 | |
| SCHEMBL492873 | 0.85 | DYRK1A (0.50) | KDM4EGSK3BIDO1NPC1RAB9A | |
| SCHEMBL1964170 | 0.85 | PDPK1 (0.50) | KDM4EGSK3BIDO1LMNADYRK1A | |
| Tert-Butyl Formate SCHEMBL27760082 | 0.79 | PDPK1 (0.43) | KDM4EGSK3BIDO1LMNADYRK1A | |
| SCHEMBL1636035 | 0.78 | KDM4E (0.66) | KDM4EGSK3BNPC1RAB9ALMNA | |
| SCHEMBL492203 | 0.78 | KDM4E (0.66) | KDM4EGSK3BIDO1NPC1RAB9A | |
| SCHEMBL23901082 | 0.72 | MAP2K4 (0.47) | KDM4EHPGDMAPK1HSD17B10NPC1 | |
| SCHEMBL498163 | 0.71 | KDM4E (0.63) | KDM4EGSK3BIDO1SMN1; SMN2DYRK1A | |
| SCHEMBL30258217 | 0.71 | KDM4E (0.63) | KDM4EGSK3BIDO1SMN1; SMN2DYRK1A | |
| SCHEMBL4291226 | 0.71 | KDM4E (0.63) | KDM4EGSK3BIDO1HTTDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | disclosed |