Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.78 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.78 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.78 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.78 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | KIF5C | O60282 | 1/20 | 0.54 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | KIF5A | Q12840 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301171 | 0.91 | PIK3CD (0.75) | PIK3CDPIK3CBPIK3CGPIK3CACSNK2A1 | |
| SCHEMBL300834 | 0.91 | PIK3CD (0.69) | PIK3CDPIK3CBPIK3CGPIK3CACSNK2A1 | |
| SCHEMBL300955 | 0.89 | PIK3CD (0.72) | PIK3CDPIK3CBPIK3CGPIK3CACSNK2A1 | |
| SCHEMBL300918 | 0.88 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CGPIK3CACSNK2A1 | |
| SCHEMBL27796448 | 0.88 | PIK3CD (0.71) | PIK3CDPIK3CBPIK3CGPIK3CACSNK2A1 | |
| SCHEMBL300865 | 0.87 | PIK3CD (0.84) | PIK3CDPIK3CBPIK3CGPIK3CACSNK2A1 | |
| SCHEMBL300970 | 0.86 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CGPIK3CACSNK2A1 | |
| SCHEMBL300915 | 0.85 | PIK3CD (0.72) | PIK3CDPIK3CBPIK3CGPIK3CACSNK2A1 | |
| SCHEMBL300830 | 0.85 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CGPIK3CACSNK2A1 | |
| SCHEMBL300925 | 0.84 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CGPIK3CACSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2012-03-14 | — | — | EP | claimed |
| CN-107976546-B | Inhibition of phosphorylation of TOR kinase inhibitory Activity markers PRAS40, GSK 3-beta, or P70S6K1 | 西格诺药品有限公司 | 2020-10-27 | — | — | CN | disclosed |
| CN-110721186-A | Treatment of prostate cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2020-01-24 | — | — | CN | disclosed |
| CN-107157990-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2020-01-07 | — | — | CN | disclosed |