Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | SRC | P12931 | 3/20 | 0.59 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.59 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.59 |
| ▸ | CIT | O14578 | 2/20 | 0.59 |
| ▸ | GAK | O14976 | 2/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.59 |
| ▸ | STK17B | O94768 | 2/20 | 0.59 |
| ▸ | STK10 | O94804 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | LYN | P07948 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | MET | P08581 | 2/20 | 0.59 |
| ▸ | HCK | P08631 | 2/20 | 0.59 |
| ▸ | FGR | P09769 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28538015 | 1.00 | EGFR (0.61) | EGFRKDRERBB2KITSRC | |
| SCHEMBL4220279 | 0.91 | EGFR (0.75) | EGFRKDRERBB2KITSRC | |
| SCHEMBL30879224 | 0.91 | EGFR (0.75) | EGFRKDRERBB2KITSRC | |
| SCHEMBL30213428 | 0.91 | EGFR (0.75) | EGFRKDRERBB2KITSRC | |
| SCHEMBL7567156 | 0.89 | EGFR (0.63) | EGFRKDRERBB2KITSRC | |
| SCHEMBL7565810 | 0.87 | EGFR (0.61) | EGFRKDRERBB2 | |
| SCHEMBL3578798 | 0.85 | EGFR (0.77) | EGFRKDRERBB2KITSRC | |
| SCHEMBL7002110 | 0.85 | EGFR (0.61) | EGFRKDR | |
| SCHEMBL3587839 | 0.84 | EGFR (0.72) | EGFRKDRERBB2KITSRC | |
| SCHEMBL5232981 | 0.84 | EGFR (0.62) | EGFRKDRERBB2KITSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12564638-B2 | EGFR protein degradant and anti-tumor application thereof | SHANGHAITECH UNIVERSITY (CN) | 2026-03-03 | — | — | US | disclosed |
| US-20220313829-A1 | EGFR PROTEIN DEGRADANT AND ANTI-TUMOR APPLICATION THEREOF | SHANGHAITECH UNIVERSITY (CN) | 2022-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220313829-A1 | EGFR PROTEIN DEGRADANT AND ANTI-TUMOR APPLICATION THEREOF | EGFR, ERBB2, ERBB3 | EGFR 1/4885KDR 112/4885ERBB2 2/4885 |
| US-12564638-B2 | EGFR protein degradant and anti-tumor application thereof | EGFR, ERBB2, ERBB3 | EGFR 1/4885KDR 35/4885ERBB2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.