Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | MET | P08581 | 1/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.61 |
| ▸ | TEC | P42680 | 1/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.61 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.61 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.61 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30126605 | 1.00 | EGFR (0.63) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL30127178 | 1.00 | EGFR (0.63) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL30127497 | 0.96 | EGFR (0.66) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL30127603 | 0.96 | EGFR (0.66) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL30127577 | 0.96 | EGFR (0.66) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL30126313 | 0.94 | EGFR (0.71) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL30127206 | 0.94 | EGFR (0.71) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL30126103 | 0.93 | EGFR (0.66) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL30126528 | 0.91 | EGFR (0.68) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL30126818 | 0.90 | EGFR (0.61) | EGFRERBB2KCNH2RIPK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4392423-A1 | QUINAZOLINE COMPOUNDS FOR TREATMENT OF DISEASE | Arthrosi Therapeutics, Inc. (US) | 2024-07-03 | — | — | EP | claimed |
| WO-2023028054-A1 | QUINAZOLINE COMPOUNDS FOR TREATMENT OF DISEASE | ARTHROSI THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | claimed |
| EP-4392423-A1 | QUINAZOLINE COMPOUNDS FOR TREATMENT OF DISEASE | Arthrosi Therapeutics, Inc. (US) | 2024-07-03 | — | — | EP | disclosed |
| WO-2023028054-A1 | QUINAZOLINE COMPOUNDS FOR TREATMENT OF DISEASE | ARTHROSI THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |
| WO-2022266458-A1 | 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |