Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.52 |
| ▸ | TEC | P42680 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30126688 | 1.00 | EGFR (0.64) | EGFRERBB2RETABL1RAF1 | |
| SCHEMBL30126818 | 0.96 | EGFR (0.61) | EGFRERBB2RETABL1RAF1 | |
| SCHEMBL30126249 | 0.96 | EGFR (0.61) | EGFRERBB2RETABL1RAF1 | |
| SCHEMBL30126337 | 0.93 | EGFR (0.66) | EGFRERBB2RETABL1RAF1 | |
| SCHEMBL30127497 | 0.90 | EGFR (0.66) | EGFRERBB2RETRIPK2MET | |
| SCHEMBL30127577 | 0.90 | EGFR (0.66) | EGFRERBB2RETRIPK2MET | |
| SCHEMBL30127603 | 0.90 | EGFR (0.66) | EGFRERBB2RETRIPK2MET | |
| SCHEMBL30126997 | 0.90 | EGFR (0.53) | EGFRERBB2RETRIPK2MET | |
| SCHEMBL30127549 | 0.90 | EGFR (0.53) | EGFRERBB2RETRIPK2MET | |
| SCHEMBL30126275 | 0.88 | EGFR (0.65) | EGFRERBB2RETABL1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266458-A1 | 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |