Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 6/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.41 |
| ▸ | FLT1 | P17948 | 4/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23538011 | 1.00 | EGFR (0.54) | EGFREPHA2ERBB2KDREPHB4 | |
| SCHEMBL30127607 | 0.91 | EGFR (0.50) | EGFRERBB2MKNK2RAF1BRAF | |
| SCHEMBL30126123 | 0.90 | EGFR (0.49) | EGFREPHA2ERBB2KDREPHB4 | |
| SCHEMBL30126870 | 0.87 | EGFR (0.47) | EGFRKDRMKNK2RAF1BRAF | |
| SCHEMBL23537741 | 0.86 | EGFR (0.51) | EGFREPHA2ERBB2KDREPHB4 | |
| SCHEMBL30127446 | 0.85 | EGFR (0.50) | EGFRERBB2KDRFLT1MKNK2 | |
| SCHEMBL30127640 | 0.85 | EGFR (0.47) | EGFRERBB2KDRFLT1MKNK2 | |
| SCHEMBL30126975 | 0.84 | EGFR (0.55) | EGFREPHA2ERBB2KDREPHB4 | |
| SCHEMBL30125973 | 0.84 | EGFR (0.45) | EGFRERBB2MKNK2RAF1BRAF | |
| SCHEMBL30127372 | 0.84 | MKNK2 (0.46) | EGFREPHA2ERBB2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266458-A1 | 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |