Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.60 |
| ▸ | IKZF2 | Q9UKS7 | 9/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.50 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21760141 | 1.00 | CRBN (0.60) | CRBNIKZF2CSNK1A1IKZF1 | |
| Hydrochloric Acid SCHEMBL31741923 | 0.99 | CRBN (0.59) | CRBNIKZF2CSNK1A1IKZF1 | |
| Hydrochloric Acid SCHEMBL31025904 | 0.93 | CRBN (0.57) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL30689611 | 0.92 | IKZF2 (0.54) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL26270904 | 0.91 | CRBN (0.61) | CRBNIKZF2CSNK1A1 | |
| SCHEMBL21759489 | 0.91 | CRBN (0.61) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL30137470 | 0.91 | CRBN (0.61) | CRBNIKZF2CSNK1A1IKZF1 | |
| Hydrochloric Acid SCHEMBL31025908 | 0.90 | CRBN (0.60) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL25576784 | 0.85 | CRBN (0.57) | CRBNIKZF2CSNK1A1 | |
| SCHEMBL25027260 | 0.84 | CRBN (0.56) | CRBNIKZF2CSNK1A1IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118530239-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-115626927-B | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-115626927-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-01-20 | — | — | CN | disclosed |
| EP-4110772-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | Cullgen (Shanghai), Inc. (CN) | 2023-01-04 | — | — | EP | disclosed |