Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 12/20 | 0.56 |
| ▸ | SRC | P12931 | 8/20 | 0.48 |
| ▸ | ABL1 | P00519 | 6/20 | 0.48 |
| ▸ | HCK | P08631 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.48 |
| ▸ | PRKDC | P78527 | 5/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | MTOR | P42345 | 4/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | FGR | P09769 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21184915 | 1.00 | RET (0.56) | RETSRCABL1HCKKDR | |
| SCHEMBL21178722 | 0.85 | RET (0.73) | RETSRCABL1HCKKDR | |
| SCHEMBL21178661 | 0.85 | RET (0.57) | RETSRCABL1HCKKDR | |
| SCHEMBL30382177 | 0.85 | RET (0.57) | RETSRCABL1HCKKDR | |
| SCHEMBL30128621 | 0.85 | RET (0.58) | RETSRCABL1HCKKDR | |
| SCHEMBL21184912 | 0.85 | RET (0.58) | RETSRCABL1HCKKDR | |
| SCHEMBL21184913 | 0.83 | RET (0.57) | RETSRCABL1HCKKDR | |
| SCHEMBL30128651 | 0.83 | RET (0.57) | RETSRCABL1HCKKDR | |
| SCHEMBL21178706 | 0.82 | RET (0.54) | RETSRCABL1HCKKDR | |
| SCHEMBL21179070 | 0.82 | RET (0.54) | RETSRCABL1HCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11524963-B2 | Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2022-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11524963-B2 | Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors | RET, ROR1, BRAF | RET 1/4885SRC 183/4885ABL1 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.