Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29430119 | 1.00 | CA1 (0.44) | CA1CA2CA7CA9CA12 | |
| SCHEMBL6565552 | 1.00 | CA1 (0.44) | CA1CA2CA7CA9CA12 | |
| SCHEMBL29407955 | 1.00 | CA1 (0.44) | CA1CA2CA7CA9CA12 | |
| SCHEMBL1768301 | 0.98 | CA1 (0.43) | CA1CA2CA7CA9CA12 | |
| SCHEMBL13593792 | 0.92 | CA1 (0.38) | CA1CA2CA7CA9CA12 | |
| SCHEMBL12083834 | 0.92 | CA12 (0.38) | CA1CA2CA7CA9CA12 | |
| SCHEMBL7289398 | 0.90 | CA1 (0.36) | CA1CA2CA7CA9CA12 | |
| SCHEMBL5573142 | 0.90 | CA1 (0.36) | CA1CA2CA7CA9CA12 | |
| SCHEMBL5195630 | 0.90 | APP (0.44) | CA1CA2CA7CA9CA12 | |
| SCHEMBL1768406 | 0.90 | TOP1 (0.41) | CA1CA2CA7CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 656 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710422-B1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY AND DIASTEREOMERICALLY ENRICHED CYCLOBUTANE AMINES AND AMIDES | SYNGENTA CROP PROTECTION AG (CH) | 2026-01-07 | — | — | EP | claimed |
| CN-118206463-A | Method for synthesizing tetrahydronaphthalene compounds through asymmetric hydrogenation of amide-guided naphthalene compounds | 中国科学院大连化学物理研究所 | 2024-06-18 | — | — | CN | claimed |
| CN-117263897-A | Chiral dibenzosubenol compound and asymmetric synthesis method thereof | 四川师范大学 | 2023-12-22 | — | — | CN | claimed |
| CN-116947580-A | Method for constructing axial chiral compound by hydrogenation and desymmetry of rhodium-catalyzed anthracene | 中国科学院大连化学物理研究所 | 2023-10-27 | — | — | CN | claimed |
| CN-116410118-A | Preparation method of beta-lactam compound | 中国科学技术大学 | 2023-07-11 | — | — | CN | claimed |
| CN-114669333-B | Catalyst system and catalytic method for catalyzing decarbonylation hydrogenation of alpha-quaternary carbon aldehyde | 中山大学 | 2023-06-23 | — | — | CN | claimed |
| CN-113754889-B | Method for synthesizing polysilicone through selective dehydrogenation coupling of polysilicone and cobalt-catalyzed latent chiral silane and diol | 中国科学院大连化学物理研究所 | 2022-10-14 | — | — | CN | claimed |
| CN-114669333-A | Catalyst system and method for catalyzing decarbonylation and hydrogenation of alpha-quaternary carbon aldehyde | 中山大学 | 2022-06-28 | — | — | CN | claimed |
| EP-2964384-B1 | AQUEOUS HYDROGENATION REACTIONS USING WATER-INSOLUBLE RUTHENIUM CATALYST COMPOSITION | DUDECHEM GMBH (DE) | 2022-05-04 | — | — | EP | claimed |
| CN-113754889-A | Method for synthesizing polysilicone through selective dehydrogenation coupling of polysilicone and cobalt-catalyzed latent chiral silane and diol | 中国科学院大连化学物理研究所 | 2021-12-07 | — | — | CN | claimed |
| US-6069245-A | PRODUCING A 3-BENZOYLAMINO-4-BENZOYLOXYHEXAHYDROAZEPINE BY THE CATALYTIC HYDROGENATION OF THE 4-OXO-AMINE SALT DERIVATIVE; PROTECTING THE RING NITROGEN; FORMING A FUSED RING; HYDROLYSIS; ACYLATION AND DEPROTECTING | HOFFMANN-LA ROCHE INC. (US) | 2000-05-30 | — | — | US | claimed |
| EP-0974590-A1 | Process for the preparation of chiral lactones by asymetrical hydrogenation | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-26 | — | — | EP | claimed |
| US-5902882-A | ASYMMETRICALLY HYDROGENATING AN AZEPINE COMPOUND IN THE PRESENCE OF A RUTHENIUM-DIPHOSPHINE COMPLEX CATALYST | HOFFMANN-LA ROCHE INC. (US) | 1999-05-11 | — | — | US | claimed |
| US-5750690-A | HYDROGENATION OF A 1,2-DIALKYLOXO-3-CARBOXY-3-PYRAZOLINE OR 1,2,5,6-TETRAHYDROPYRIDAZINE OR DERIVATIVE; INTERMEDIATES FOR THE HYPOTENSIVE AGENT, ?CILAZAPRIL? | HOFFMANN-LA ROCHE INC. (US) | 1998-05-12 | — | — | US | claimed |
| EP-0802190-A1 | Process and intermediates for preparing azepines | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-22 | — | — | EP | claimed |
| US-5600015-A | USING RUTHENIUM COMPLEX OF OPTICALLY ACTIVE ATROPISOMERIC DIPHOSPHINE LIGAND AS HYDROGENATION CATALYST | HOFFMANN-LA ROCHE INC. (US) | 1997-02-04 | — | — | US | claimed |
| US-5488172-A | Chiral phosphorus compounds | HOFFMANN-LA ROCHE INC. (US) | 1996-01-30 | — | — | US | claimed |
| EP-0492401-B1 | Asymmetric hydrogenation | CIBA GEIGY AG (CH) | 1996-01-24 | — | — | EP | claimed |
| EP-0398132-B1 | Phosphorous compounds | HOFFMANN LA ROCHE (CH) | 1995-09-20 | — | — | EP | claimed |
| EP-0248800-B1 | Process for making crosslinkable compositions | BICC PLC (GB) | 1995-08-23 | — | — | EP | claimed |