⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31322076 | 0.76 | — | — | |
| Acetic Acid SCHEMBL31543609 | 0.72 | — | — | |
| SCHEMBL91526 | 0.71 | — | — | |
| SCHEMBL27282431 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL1189462 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL9146158 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL30077928 | 0.69 | — | — | |
| SCHEMBL5703304 | 0.68 | SLC6A2 (0.33) | — | |
| SCHEMBL24876346 | 0.67 | — | — | |
| SCHEMBL23960072 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367117-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | Incyte Corporation (US) | 2024-05-15 | — | — | EP | disclosed |
| CN-117881680-A | Tricyclic compounds as KRAS inhibitors | 因赛特公司 | 2024-04-12 | — | — | CN | disclosed |
| WO-2023283213-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2023-01-12 | — | — | WO | disclosed |