Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.60 |
| ▸ | LPL | P06858 | 12/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 12/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15288113 | 1.00 | IRAK4 (0.60) | IRAK4LPLLIPGFFAR1NOTUM | |
| SCHEMBL31731047 | 0.90 | IRAK4 (0.56) | IRAK4LPLLIPGFFAR1F11 | |
| SCHEMBL29357103 | 0.88 | IRAK4 (0.50) | IRAK4LPLLIPGFFAR1PDE1C | |
| SCHEMBL858552 | 0.88 | IRAK4 (0.50) | IRAK4LPLLIPGFFAR1PDE1C | |
| SCHEMBL17310432 | 0.84 | IRAK4 (0.56) | IRAK4LPLLIPGFFAR1NOTUM | |
| SCHEMBL30381447 | 0.84 | IRAK4 (0.56) | IRAK4LPLLIPGFFAR1NOTUM | |
| SCHEMBL29041436 | 0.84 | IRAK4 (0.58) | IRAK4LPLLIPGFFAR1F11 | |
| SCHEMBL17678139 | 0.82 | IRAK4 (0.51) | IRAK4LPLLIPGFFAR1 | |
| SCHEMBL17678313 | 0.82 | IRAK4 (0.51) | IRAK4LPLLIPGFFAR1 | |
| SCHEMBL30381461 | 0.81 | IRAK4 (0.56) | IRAK4LPLLIPGFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367117-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | Incyte Corporation (US) | 2024-05-15 | — | — | EP | disclosed |
| EP-4168411-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION | PMV Pharmaceuticals, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| WO-2023283213-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2023-01-12 | — | — | WO | disclosed |