Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 1/20 | 0.55 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23727973 | 1.00 | LATS1 (0.55) | LATS1LATS2BRD4MAP2K1ADORA2A | |
| SCHEMBL23727975 | 1.00 | LATS1 (0.55) | LATS1LATS2BRD4MAP2K1ADORA2A | |
| SCHEMBL23727976 | 1.00 | LATS1 (0.55) | LATS1LATS2BRD4MAP2K1ADORA2A | |
| SCHEMBL23727497 | 0.88 | LATS1 (0.64) | LATS1LATS2MAP2K1ADORA2APKM | |
| SCHEMBL23727499 | 0.88 | LATS1 (0.64) | LATS1LATS2MAP2K1ADORA2APKM | |
| SCHEMBL23727208 | 0.84 | LATS1 (0.63) | LATS1LATS2MAP2K1ADORA2APKM | |
| SCHEMBL30130820 | 0.84 | LATS1 (0.63) | LATS1LATS2MAP2K1ADORA2APKM | |
| SCHEMBL23727206 | 0.84 | LATS1 (0.63) | LATS1LATS2MAP2K1ADORA2APKM | |
| SCHEMBL23749898 | 0.82 | LATS1 (0.57) | LATS1LATS2MAP2K1CYP3A4KDR | |
| SCHEMBL23750053 | 0.82 | LATS1 (0.58) | LATS1LATS2MAP2K1CDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100008-A1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | The Rockefeller University (US) | 2022-12-14 | — | — | EP | disclosed |