Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.48 |
| ▸ | JAK3 | P52333 | 10/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | STAT5B | P51692 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | STAT5A | P42229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3020094 | 0.92 | JAK2 (0.49) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL3025255 | 0.89 | JAK3 (0.54) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL3013727 | 0.87 | JAK2 (0.64) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL5029672 | 0.86 | NTRK1 (0.53) | JAK2JAK3NTRK1CDK2AURKA | |
| SCHEMBL29073152 | 0.86 | NTRK1 (0.54) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL29073154 | 0.86 | NTRK1 (0.54) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL3772070 | 0.83 | JAK2 (0.62) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL2513814 | 0.83 | JAK3 (0.59) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL3008289 | 0.82 | NTRK1 (0.44) | JAK2JAK3NTRK1AURKBCDK2 | |
| SCHEMBL3020117 | 0.81 | JAK3 (0.55) | JAK2JAK3NTRK1AURKBCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204246-A1 | 5-AMINOPYRAZOL-3-YL-3H-IMIDAZO (4,5-B) PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204246-A1 | 5-AMINOPYRAZOL-3-YL-3H-IMIDAZO (4,5-B) PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ABL1, MCL1, ETV6 | JAK2 4/4885JAK3 10/4885NTRK1 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.