SCHEMBL30134102

SCHEMBL30134102

CC(O)c1ccc(C(F)(F)F)cc1F

nearest known ligand 0.77

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PDE2A O00408 16/20 0.77
LIPG Q9Y5X9 1/20 0.40
GAA P10253 1/20 0.40
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
SLC6A3 Q01959 1/20 0.39
IDO1 P14902 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18075380 1.00 PDE2A (0.77) PDE2ALIPGGAASLC6A2SLC6A4
SCHEMBL1035450 0.87 PDE2A (1.00) PDE2AGAASLC6A2SLC6A4SLC6A3
SCHEMBL18290607 0.87 PDE2A (0.59) PDE2A
SCHEMBL2272447 0.86 PDE2A (0.58) PDE2A
SCHEMBL2272444 0.86 PDE2A (0.58) PDE2A
SCHEMBL2272449 0.86 PDE2A (0.58) PDE2A
SCHEMBL25376231 0.85 PDE2A (0.57) PDE2ALIPG
SCHEMBL10107301 0.85 PDE2A (0.61) PDE2ALIPGGAASLC6A2SLC6A4
SCHEMBL84521 0.84 PDE2A (0.70) PDE2AIDO1
SCHEMBL30481795 0.82 PDE2A (0.68) PDE2ALIPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658655-A1 CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITOR OF DIACYLGLYCEROL KINASES Beone Medicines I GmbH (CH) 2025-12-10 EP disclosed
CN-119119033-A Pyrazolopyridone compounds 百济神州有限公司 2024-12-13 CN disclosed
CN-119060036-A ATF6 inhibitors and uses thereof 阿尔托斯实验室公司 2024-12-03 CN disclosed
EP-4457224-A1 HETEROCYCLIC COMPOUNDS BeiGene Switzerland GmbH (CH) 2024-11-06 EP disclosed
CN-112313224-B ATF6 inhibitors and uses thereof 阿尔托斯实验室公司 2024-08-13 CN disclosed
WO-2024160278-A1 CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITOR OF DIACYLGLYCEROL KINASES BEIGENE, LTD. (KY) 2024-08-08 WO disclosed
CN-118451073-A Heterocyclic compounds 百济神州有限公司 2024-08-06 CN disclosed
EP-4380936-A1 PYRAZOLOPYRIDINONE COMPOUNDS BeiGene, Ltd. (KY) 2024-06-12 EP disclosed
CN-117836296-A Pyrazolopyridone compounds 百济神州有限公司 2024-04-05 CN disclosed
WO-2023125681-A1 HETEROCYCLIC COMPOUNDS BEIGENE, LTD. (KY) 2023-07-06 WO disclosed
WO-2023011456-A1 PYRAZOLOPYRIDINONE COMPOUNDS BEIGENE, LTD. (KY) 2023-02-09 WO disclosed