Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.65 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30135871 | 0.92 | CRBN (0.57) | CRBNDDB1IKZF3AR | |
| SCHEMBL29683622 | 0.85 | CRBN (0.63) | CRBNDDB1IKZF3ARALDH1A1 | |
| SCHEMBL20046181 | 0.85 | CRBN (0.70) | CRBNDDB1IKZF3ALDH1A1TSHR | |
| SCHEMBL31589896 | 0.85 | CRBN (0.70) | CRBNDDB1IKZF3ALDH1A1TSHR | |
| SCHEMBL29547640 | 0.85 | CRBN (0.70) | CRBNDDB1IKZF3ALDH1A1TSHR | |
| SCHEMBL31605512 | 0.85 | CRBN (0.70) | CRBNDDB1IKZF3ALDH1A1TSHR | |
| SCHEMBL31589236 | 0.85 | CRBN (0.70) | CRBNDDB1IKZF3ALDH1A1TSHR | |
| SCHEMBL31605528 | 0.85 | CRBN (0.70) | CRBNDDB1IKZF3ALDH1A1TSHR | |
| SCHEMBL25830336 | 0.84 | CRBN (0.60) | CRBNDDB1 | |
| SCHEMBL30066511 | 0.84 | CRBN (0.54) | CRBNDDB1IKZF3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4384520-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2024-06-19 | — | — | EP | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017442-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |