Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.80 |
| ▸ | INSR | P06213 | 10/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.70 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.70 |
| ▸ | FES | P07332 | 1/20 | 0.70 |
| ▸ | FER | P16591 | 1/20 | 0.70 |
| ▸ | FLT4 | P35916 | 1/20 | 0.70 |
| ▸ | FLT3 | P36888 | 1/20 | 0.70 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.70 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.70 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.70 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.70 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.70 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.70 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.70 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2061872 | 0.89 | ALK (1.00) | ALKINSRPTK2NUAK1CHEK2 | |
| SCHEMBL886401 | 0.87 | ALK (0.80) | ALKINSRPTK2NUAK1CHEK2 | |
| SCHEMBL2061967 | 0.85 | ALK (0.90) | ALKINSRPTK2NUAK1CHEK2 | |
| SCHEMBL2061659 | 0.84 | ALK (0.75) | ALKINSRPTK2NUAK1CHEK2 | |
| SCHEMBL2062681 | 0.83 | ALK (0.83) | ALKINSRPTK2NUAK1CHEK2 | |
| SCHEMBL2061562 | 0.83 | ALK (1.00) | ALKINSRPTK2NUAK1CHEK2 | |
| SCHEMBL2061896 | 0.83 | ALK (1.00) | ALKINSRPTK2NUAK1CHEK2 | |
| SCHEMBL2061706 | 0.82 | ALK (1.00) | ALKINSRPTK2NUAK1CHEK2 | |
| SCHEMBL2061702 | 0.82 | ALK (1.00) | ALKINSRPTK2NUAK1CHEK2 | |
| SCHEMBL29489148 | 0.82 | ALK (1.00) | ALKINSRPTK2NUAK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |