Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.81 |
| ▸ | WEE1 | P30291 | 6/20 | 0.78 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.78 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.78 |
| ▸ | AURKA | O14965 | 3/20 | 0.78 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.78 |
| ▸ | JAK2 | O60674 | 3/20 | 0.78 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.78 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.78 |
| ▸ | PAK4 | O96013 | 3/20 | 0.78 |
| ▸ | LCK | P06239 | 3/20 | 0.78 |
| ▸ | FYN | P06241 | 3/20 | 0.78 |
| ▸ | CSF1R | P07333 | 3/20 | 0.78 |
| ▸ | RET | P07949 | 3/20 | 0.78 |
| ▸ | IGF1R | P08069 | 3/20 | 0.78 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.78 |
| ▸ | PRKACA | P17612 | 3/20 | 0.78 |
| ▸ | FLT1 | P17948 | 3/20 | 0.78 |
| ▸ | LTK | P29376 | 3/20 | 0.78 |
| ▸ | KDR | P35968 | 3/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3767432 | 0.88 | ALK (1.00) | EGFRWEE1ALKPDGFRAAURKA | |
| SCHEMBL30138099 | 0.83 | EGFR (0.80) | EGFRWEE1ALKPDGFRAAURKA | |
| SCHEMBL28942655 | 0.83 | EGFR (0.80) | EGFRWEE1ALKPDGFRAAURKA | |
| SCHEMBL24625518 | 0.80 | EGFR (1.00) | EGFRBRD4 | |
| SCHEMBL3759654 | 0.78 | EGFR (0.83) | EGFRWEE1ALKPDGFRAAURKA | |
| SCHEMBL3714937 | 0.78 | PDGFRA (1.00) | EGFRWEE1ALKPDGFRAAURKA | |
| SCHEMBL30395234 | 0.77 | CCNA2 (1.00) | WEE1ALKPDGFRAAURKADAPK3 | |
| SCHEMBL12694650 | 0.75 | ALK (0.61) | EGFRWEE1ALKPDGFRAAURKA | |
| SCHEMBL3118367 | 0.75 | ALK (0.61) | EGFRWEE1ALKPDGFRAAURKA | |
| SCHEMBL3112708 | 0.75 | ALK (0.63) | EGFRWEE1ALKPDGFRAAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115477639-B | Polysubstituted pyrimidine compound with FGFR1 as target point, and preparation method and application thereof | 温州医科大学 | 2023-11-03 | — | — | CN | disclosed |
| CN-115477639-A | Multi-substituted pyrimidine compound with FGFR1 as target spot, and preparation method and application thereof | 温州医科大学 | 2022-12-16 | — | — | CN | disclosed |