Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.62 |
| ▸ | AURKA | O14965 | 4/20 | 0.62 |
| ▸ | TTK | P33981 | 1/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 5/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.45 |
| ▸ | LCK | P06239 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536960 | 0.90 | MAPKAPK5 (0.62) | MAPKAPK5AURKBAURKATTKPTK6 | |
| SCHEMBL5571621 | 0.85 | MAPKAPK5 (0.62) | MAPKAPK5AURKBAURKATTKPTK6 | |
| SCHEMBL1674071 | 0.84 | MAPKAPK5 (0.70) | MAPKAPK5AURKBAURKAPTK6CHEK1 | |
| SCHEMBL8246047 | 0.84 | FYN (0.52) | MAPKAPK5AURKBAURKATTKPTK6 | |
| SCHEMBL14530402 | 0.84 | MAPKAPK5 (0.58) | MAPKAPK5AURKBAURKATTKPTK6 | |
| SCHEMBL4399765 | 0.84 | MAPKAPK5 (0.58) | MAPKAPK5AURKBAURKATTKPTK6 | |
| SCHEMBL15063040 | 0.83 | MAPKAPK5 (0.69) | MAPKAPK5AURKBAURKAPTK6LCK | |
| SCHEMBL14536829 | 0.82 | MAPKAPK5 (0.52) | MAPKAPK5AURKBAURKATTKPTK6 | |
| SCHEMBL5573273 | 0.82 | MAPKAPK5 (0.64) | MAPKAPK5AURKBAURKATTKPTK6 | |
| SCHEMBL14536802 | 0.82 | PTK6 (0.54) | MAPKAPK5AURKBAURKAPTK6CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115485279-A | Antibacterial 8-phenylamino-3- (pyrazol-4-yl) imidazo [1,2-a ] pyrazine derivatives | 豪夫迈·罗氏有限公司 | 2022-12-16 | — | — | CN | disclosed |