Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.36 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4215554 | 0.83 | CDK4 (0.42) | BTKGSK3BCDK4CCND3TLR9 | |
| SCHEMBL4222561 | 0.81 | CDK4 (0.41) | BTKGSK3BCDK4CCND3PI4KA | |
| SCHEMBL4233087 | 0.75 | GRM5 (0.54) | GSK3BPI4KBTLR9TLR8TLR7 | |
| SCHEMBL4227244 | 0.75 | TLR7 (0.50) | PI4KBTLR9TLR8TLR7PIK3CA | |
| SCHEMBL4049229 | 0.75 | ADORA2A (0.47) | CDK4CCND3TLR9TLR8TLR7 | |
| SCHEMBL4218178 | 0.74 | TLR7 (0.50) | GSK3BCDK4CCND3TLR9TLR8 | |
| SCHEMBL4220294 | 0.74 | TLR7 (0.47) | BTKTLR9TLR8TLR7PIK3CA | |
| SCHEMBL4215652 | 0.73 | MTOR (0.39) | GSK3BTLR9TLR8TLR7PIK3CA | |
| SCHEMBL30861079 | 0.73 | PI4KB (0.55) | BTKGSK3BPI4KAPI4K2BPI4K2A | |
| SCHEMBL27228218 | 0.73 | PI4KB (0.55) | BTKGSK3BPI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022270994-A1 | NOVEL BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF | 한국화학연구원 | 2022-12-29 | — | — | WO | disclosed |