Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.39 |
| ▸ | TEC | P42680 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.39 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30140132 | 1.00 | EGFR (0.43) | EGFRERBB2GPR119PIK3CDPIK3CA | |
| SCHEMBL30140150 | 0.97 | EGFR (0.44) | EGFRERBB2GPR119PIK3CDPIK3CA | |
| SCHEMBL30140335 | 0.91 | EGFR (0.44) | EGFRERBB2GPR119PIK3CDPIK3CA | |
| SCHEMBL30140157 | 0.91 | EGFR (0.44) | EGFRERBB2GPR119PIK3CDPIK3CA | |
| SCHEMBL30140204 | 0.91 | EGFR (0.46) | EGFRERBB2GPR119PIK3CDPIK3CA | |
| SCHEMBL30140202 | 0.90 | EGFR (0.43) | EGFRERBB2GPR119PIK3CDPIK3CA | |
| SCHEMBL30140230 | 0.90 | EGFR (0.45) | EGFRERBB2GPR119PIK3CDPIK3CA | |
| SCHEMBL30140147 | 0.90 | EGFR (0.55) | EGFRERBB2RIPK2RETMET | |
| SCHEMBL30140450 | 0.89 | EGFR (0.45) | EGFRERBB2GPR119PIK3CDPIK3CA | |
| SCHEMBL30140267 | 0.89 | EGFR (0.45) | EGFRERBB2GPR119PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266426-A1 | 6-(HETEROCYCLOALKYL-OXY)-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |