Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | FLT4 | P35916 | 2/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30140124 | 0.85 | ERBB2 (0.49) | EGFRERBB2EPHA2KDRFLT1 | |
| SCHEMBL30140323 | 0.84 | EGFR (0.39) | EGFRERBB2KDRFGFR1FLT1 | |
| SCHEMBL30140186 | 0.84 | EGFR (0.45) | EGFRERBB2CHRNB2CHRNA4 | |
| SCHEMBL30140360 | 0.80 | EGFR (0.45) | EGFRERBB2EPHA2KDRFGFR1 | |
| SCHEMBL30140321 | 0.79 | EGFR (0.46) | EGFRERBB2EPHA2KDREPHB4 | |
| SCHEMBL30140192 | 0.79 | EGFR (0.63) | EGFRERBB2 | |
| SCHEMBL30140339 | 0.78 | EGFR (0.41) | EGFRERBB2EPHA2KDRFGFR1 | |
| SCHEMBL30140400 | 0.77 | EGFR (0.42) | EGFRERBB2CHRNB2CHRNA4 | |
| SCHEMBL30140153 | 0.76 | EGFR (0.43) | EGFRERBB2EPHA2KDRFGFR1 | |
| SCHEMBL30140058 | 0.75 | EGFR (0.43) | EGFRERBB2EPHA2KDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266426-A1 | 6-(HETEROCYCLOALKYL-OXY)-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |