Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30140071 | 0.90 | EGFR (0.55) | EGFRERBB2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30140085 | 0.89 | EGFR (0.60) | EGFRERBB2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30140060 | 0.88 | EGFR (0.71) | EGFRERBB2 | |
| SCHEMBL30140181 | 0.87 | EGFR (0.54) | EGFRERBB2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30140113 | 0.86 | EGFR (0.46) | EGFRERBB2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30140112 | 0.85 | EGFR (0.52) | EGFRERBB2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30140307 | 0.85 | EGFR (0.52) | EGFRERBB2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30140251 | 0.85 | EGFR (0.56) | EGFRERBB2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22598569 | 0.84 | ERBB2 (0.73) | EGFRERBB2EPHA2EPHB4KDR | |
| SCHEMBL29465789 | 0.84 | ERBB2 (0.73) | EGFRERBB2EPHA2EPHB4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266426-A1 | 6-(HETEROCYCLOALKYL-OXY)-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |