SCHEMBL30141386

SCHEMBL30141386

CCc1nn(CC2CCC(F)(F)C2)c(C(=O)Nc2ccnc(S(C)(=O)=O)c2)c1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 19/20 0.43
ANO1 Q5XXA6 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24906221 1.00 SCN10A (0.43) SCN10AANO1
SCHEMBL24906409 0.94 SCN10A (0.46) SCN10A
SCHEMBL24758288 0.91 SCN10A (0.45) SCN10A
SCHEMBL24757812 0.90 SCN10A (0.44) SCN10AANO1
SCHEMBL30141364 0.89 SCN10A (0.43) SCN10A
SCHEMBL24906297 0.89 SCN10A (0.43) SCN10A
SCHEMBL24906440 0.89 SCN10A (0.43) SCN10A
SCHEMBL24757831 0.89 SCN10A (0.43) SCN10A
SCHEMBL24906296 0.88 ANO1 (0.43) SCN10AANO1
SCHEMBL24757301 0.87 SCN10A (0.42) SCN10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4355733-A1 SUBSTITUTED PYRAZOLE AMIDES Grünenthal GmbH (DE) 2024-04-24 EP claimed
WO-2022263498-A1 SUBSTITUTED PYRAZOLE AMIDES Grünenthal GmbH (DE) 2022-12-22 WO claimed
EP-4355733-A1 SUBSTITUTED PYRAZOLE AMIDES Grünenthal GmbH (DE) 2024-04-24 EP disclosed
WO-2022263498-A1 SUBSTITUTED PYRAZOLE AMIDES Grünenthal GmbH (DE) 2022-12-22 WO disclosed