Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.51 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20985258 | 1.00 | MAPT (0.52) | MAPTCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL30144393 | 1.00 | MAPT (0.52) | MAPTCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL20985419 | 1.00 | MAPT (0.52) | MAPTCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL23860136 | 1.00 | MAPT (0.52) | MAPTCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL30144472 | 1.00 | MAPT (0.52) | MAPTCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL23860180 | 1.00 | MAPT (0.52) | MAPTCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL30144174 | 1.00 | MAPT (0.52) | MAPTCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL23908308 | 0.97 | CRBN (0.53) | MAPTCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL23860143 | 0.95 | MAPT (0.51) | MAPTCRBNDDB1GSPT1ALDH1A1 | |
| SCHEMBL30144209 | 0.95 | MAPT (0.51) | MAPTCRBNDDB1GSPT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121422-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |