Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.68 |
| ▸ | LCK | P06239 | 5/20 | 0.68 |
| ▸ | SRC | P12931 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | TEK | Q02763 | 1/20 | 0.68 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.67 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.67 |
| ▸ | LYN | P07948 | 2/20 | 0.66 |
| ▸ | EGFR | P00533 | 4/20 | 0.59 |
| ▸ | ITK | Q08881 | 3/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | YES1 | P07947 | 1/20 | 0.54 |
| ▸ | HCK | P08631 | 1/20 | 0.54 |
| ▸ | FGR | P09769 | 1/20 | 0.54 |
| ▸ | FER | P16591 | 1/20 | 0.54 |
| ▸ | CSK | P41240 | 1/20 | 0.54 |
| ▸ | TEC | P42680 | 1/20 | 0.54 |
| ▸ | BLK | P51451 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24196821 | 1.00 | BTK (0.68) | BTKLCKSRCKDRTEK | |
| SCHEMBL22720911 | 0.97 | BTK (0.71) | BTKLCKSRCKDRTEK | |
| SCHEMBL29439261 | 0.97 | BTK (0.71) | BTKLCKSRCKDRTEK | |
| SCHEMBL30144775 | 0.95 | BTK (0.65) | BTKLCKSRCKDRTEK | |
| SCHEMBL25075181 | 0.95 | BTK (0.65) | BTKLCKSRCKDRTEK | |
| SCHEMBL26495555 | 0.95 | BTK (0.69) | BTKLCKSRCKDRTEK | |
| SCHEMBL26096706 | 0.95 | BTK (0.69) | BTKLCKSRCKDRTEK | |
| SCHEMBL30144752 | 0.95 | BTK (0.69) | BTKLCKSRCKDRTEK | |
| SCHEMBL24196548 | 0.94 | BTK (0.66) | BTKLCKSRCKDRTEK | |
| SCHEMBL22720853 | 0.94 | BTK (0.66) | BTKLCKSRCKDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116134028-A | Compound capable of degrading BTK kinase, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2023-05-16 | — | — | CN | disclosed |
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |