Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 17/20 | 0.55 |
| ▸ | CD274 | Q9NZQ7 | 17/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20294221 | 1.00 | PDCD1 (0.55) | PDCD1CD274PRMT5WDR77MAPK8 | |
| SCHEMBL21565000 | 0.91 | PDCD1 (0.58) | PDCD1CD274 | |
| SCHEMBL30145362 | 0.88 | PDCD1 (0.53) | PDCD1CD274MAPK8GRAMD1A | |
| SCHEMBL20293195 | 0.88 | PDCD1 (0.53) | PDCD1CD274MAPK8GRAMD1A | |
| SCHEMBL30010862 | 0.87 | PDCD1 (0.46) | PDCD1CD274MAPK8GRAMD1A | |
| SCHEMBL20293591 | 0.87 | PDCD1 (0.54) | PDCD1CD274MAPK8 | |
| SCHEMBL29812811 | 0.87 | PDCD1 (0.54) | PDCD1CD274MAPK8 | |
| SCHEMBL22675301 | 0.85 | PDCD1 (0.59) | PDCD1CD274 | |
| SCHEMBL20294264 | 0.84 | PDCD1 (0.81) | PDCD1CD274 | |
| SCHEMBL20294297 | 0.84 | PDCD1 (0.66) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118908978-A | Tetrahydro-imidazo [4,5-c ] pyridine derivatives as PD-L1 immunomodulators | 因赛特公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-112752756-B | Tetrahydro-imidazo [4,5-c ] pyridine derivatives as PD-L1 immunomodulators | 因赛特公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-110267953-B | Tetrahydroimidazo [4,5-C ] pyridine derivatives as inducers of PD-L1 internalization | 因赛特公司 | 2022-12-20 | — | — | CN | disclosed |