Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | AR | P10275 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3019911 | 0.94 | SMN1; SMN2 (0.63) | SMN1; SMN2L3MBTL1ALDH1A1MAPK1NPC1 | |
| SCHEMBL3017457 | 0.91 | SMN1; SMN2 (0.51) | SMN1; SMN2L3MBTL1ALDH1A1MAPK1NPC1 | |
| SCHEMBL3016724 | 0.91 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1ALDH1A1MAPK1NPC1 | |
| SCHEMBL3001913 | 0.89 | SMN1; SMN2 (0.61) | SMN1; SMN2L3MBTL1ALDH1A1MAPK1NPC1 | |
| SCHEMBL3003995 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1ALDH1A1MAPK1NPC1 | |
| SCHEMBL3001102 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1ALDH1A1MAPK1NPC1 | |
| SCHEMBL3012975 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1ALDH1A1MAPK1NPC1 | |
| SCHEMBL3009419 | 0.89 | SMN1; SMN2 (0.60) | SMN1; SMN2L3MBTL1ALDH1A1MAPK1NPC1 | |
| SCHEMBL3011753 | 0.89 | KMT2A (0.58) | SMN1; SMN2L3MBTL1ALDH1A1MAPK1NPC1 | |
| SCHEMBL3000842 | 0.89 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1ALDH1A1MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722681-B2 | N-sulfonyl thiazolylpiperazine derivatives and related N-sulfonyl heterocyclic derivatives for the treatment of neuro degenerative diseases | NV REMYND (BE) | 2014-05-13 | — | — | US | disclosed |
| US-20100197703-A1 | N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197703-A1 | N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | SMN1; SMN2, HTT, SNCA | SMN1; SMN2 1/4885L3MBTL1 1847/4885ALDH1A1 3510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.