SCHEMBL30146480

SCHEMBL30146480

Fc1cncc2c1c(N1CCCc3c(C#CC4(C(F)(F)F)CC4)cccc31)nc1nncn12

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.33
STAT3 P40763 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24806399 1.00 MAPT (0.33) MAPTSTAT3KMT2A
SCHEMBL23577859 0.91 MAPT (0.36) MAPTSTAT3KMT2A
SCHEMBL29909054 0.89 MAPT (0.33) MAPTSTAT3KMT2A
SCHEMBL23577075 0.89 MAPT (0.33) MAPTSTAT3KMT2A
SCHEMBL30146469 0.89 MAPT (0.34) MAPTSTAT3KMT2A
SCHEMBL24806321 0.89 MAPT (0.34) MAPTSTAT3KMT2A
SCHEMBL30146475 0.88 STAT3 (0.31) MAPTSTAT3KMT2A
SCHEMBL24807469 0.88 STAT3 (0.31) MAPTSTAT3KMT2A
SCHEMBL24816000 0.87 STAT3 (0.36) MAPTSTAT3KMT2A
SCHEMBL30049454 0.87 STAT3 (0.36) MAPTSTAT3KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4359413-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2024-05-01 EP disclosed
WO-2022271650-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-12-29 WO disclosed