SCHEMBL30146504

SCHEMBL30146504

Cc1nnc2nc(N(CC(F)F)c3cc(F)cc(C#CC(C)(C)O)c3)c3c(F)cncc3n12

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TNIK Q9UKE5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24806373 1.00 TNIK (0.32) TNIK
SCHEMBL24806296 0.91
SCHEMBL30146409 0.91
SCHEMBL29909432 0.89 TNIK (0.32) TNIK
SCHEMBL23576980 0.89 TNIK (0.32) TNIK
SCHEMBL24814750 0.88 TNIK (0.31) TNIK
SCHEMBL30049214 0.88 TNIK (0.31) TNIK
SCHEMBL23601475 0.87 TNIK (0.32) TNIK
SCHEMBL24806297 0.86 TNIK (0.33) TNIK
SCHEMBL30146542 0.86 TNIK (0.33) TNIK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4359413-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2024-05-01 EP disclosed
WO-2022271650-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-12-29 WO disclosed