Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 11/20 | 0.43 |
| ▸ | KDM5A | P29375 | 3/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM4B | O94953 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18256005 | 0.79 | PARP1 (0.44) | PARP1DAOKDM4CKDM5A | |
| SCHEMBL1382913 | 0.74 | PARP1 (0.42) | PARP1DAOCSNK2A1 | |
| SCHEMBL18256632 | 0.71 | KDM4E (0.43) | PARP1DAOKDM4CKDM5AKDM4A | |
| SCHEMBL18256035 | 0.69 | RXFP1 (0.45) | PARP1DAOKDM4CFEN1 | |
| SCHEMBL21543791 | 0.68 | KDM4E (0.40) | PARP1DAOKDM4CMAPTKDM4A | |
| SCHEMBL30300398 | 0.68 | KDM4E (0.40) | PARP1DAOKDM4CMAPTKDM4A | |
| SCHEMBL16695706 | 0.66 | PARP1 (0.68) | PARP1 | |
| SCHEMBL10134605 | 0.63 | PARP1 (0.79) | PARP1DAOKDM5AKDM5CKDM5B | |
| SCHEMBL10134606 | 0.63 | PARP1 (0.79) | PARP1DAOKDM4CKDM5AFEN1 | |
| SCHEMBL29484414 | 0.63 | PARP1 (0.79) | PARP1DAOKDM5AKDM5CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359413-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022271650-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-12-29 | — | — | WO | disclosed |