Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 13/20 | 0.49 |
| ▸ | JAK3 | P52333 | 13/20 | 0.49 |
| ▸ | JAK1 | P23458 | 12/20 | 0.49 |
| ▸ | JAK2 | O60674 | 10/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23878772 | 1.00 | TYK2 (0.49) | TYK2JAK3JAK1JAK2PAK1 | |
| SCHEMBL22053998 | 1.00 | TYK2 (0.49) | TYK2JAK3JAK1JAK2PAK1 | |
| SCHEMBL24996388 | 0.92 | JAK3 (0.48) | TYK2JAK3JAK1JAK2PAK1 | |
| SCHEMBL23878952 | 0.88 | TYK2 (0.49) | TYK2JAK3JAK1JAK2PAK4 | |
| SCHEMBL22054218 | 0.88 | TYK2 (0.49) | TYK2JAK3JAK1JAK2PAK4 | |
| SCHEMBL30146792 | 0.88 | TYK2 (0.49) | TYK2JAK3JAK1JAK2PAK4 | |
| SCHEMBL23878761 | 0.87 | JAK3 (0.53) | TYK2JAK3JAK1JAK2PAK1 | |
| SCHEMBL22054000 | 0.87 | JAK3 (0.53) | TYK2JAK3JAK1JAK2PAK1 | |
| SCHEMBL22054602 | 0.87 | TYK2 (0.57) | TYK2JAK3JAK1JAK2PAK1 | |
| SCHEMBL23878951 | 0.87 | TYK2 (0.57) | TYK2JAK3JAK1JAK2PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116003441-B | Heteroaromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2025-06-10 | — | — | CN | disclosed |
| CN-115925705-B | Heteroaromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-12-31 | — | — | CN | disclosed |
| CN-116003441-A | Heteroaromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-115925705-A | Heteroaromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-115667228-A | Salt and crystal form of heteroaromatic derivative and preparation method of salt and crystal form | 上海翰森生物医药科技有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-111511738-B | Heteroaromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-01-20 | — | — | CN | disclosed |