Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.60 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22644533 | 1.00 | HCAR2 (0.60) | HCAR2RAF1PTGS1PTGS2SCN10A | |
| SCHEMBL30367991 | 0.87 | HCAR2 (0.55) | HCAR2RAF1PTGS1PTGS2SCN10A | |
| SCHEMBL5909485 | 0.86 | RAF1 (0.53) | HCAR2RAF1PTGS1PTGS2HDAC6 | |
| SCHEMBL23167326 | 0.82 | HCAR2 (0.62) | HCAR2PTGS1PTGS2HDAC6HDAC1 | |
| SCHEMBL289817 | 0.82 | HCAR2 (0.49) | HCAR2PTGS1PTGS2HDAC6HDAC1 | |
| SCHEMBL5479141 | 0.81 | KDM4E (0.62) | HCAR2PTGS1PTGS2SCN10AHDAC6 | |
| SCHEMBL21607970 | 0.78 | RAF1 (0.48) | RAF1PTGS1PTGS2HDAC6KDM4E | |
| SCHEMBL3168799 | 0.78 | KDM4E (0.59) | RAF1KDM4EALDH1A1MKNK1MKNK2 | |
| SCHEMBL10274534 | 0.78 | HCAR2 (0.62) | HCAR2RAF1PTGS2KDM4EALDH1A1 | |
| SCHEMBL2722765 | 0.78 | HCAR2 (0.67) | HCAR2PTGS1PTGS2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4395828-A1 | BIFUNCTIONAL DEGRADERS COMPRISING A TEAD BINDER | Novartis AG (CH) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023031801-A1 | BIFUNCTIONAL DEGRADERS COMPRISING A TEAD BINDER | NOVARTIS AG (CH) | 2023-03-09 | — | — | WO | disclosed |
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |