Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tecnazene SCHEMBL64355 | 1.00 | TSHR (1.00) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5579130 | 0.86 | TSHR (0.75) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5921857 | 0.85 | TSHR (0.74) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7607838 | 0.84 | TSHR (0.72) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1625816 | 0.84 | TSHR (0.72) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5064995 | 0.84 | TSHR (0.72) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL202953 | 0.84 | TSHR (0.72) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL203338 | 0.84 | TSHR (0.72) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL11125778 | 0.84 | TSHR (0.72) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL14211584 | 0.84 | TSHR (0.72) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492328-B2 | Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-07-23 | — | — | US | disclosed |
| EP-2559771-A2 | Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators | Bristol-Myers Squibb Company (US) | 2013-02-20 | — | — | EP | disclosed |
| US-20100184125-A1 | BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO INSULIN GROWTH FACTOR-1 RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-07-22 | — | — | US | disclosed |