Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 1.00 |
| ▸ | MAP3K7 | O43318 | 17/20 | 1.00 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | PRKCG | P05129 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19742917 | 1.00 | IRAK4 (1.00) | IRAK4MAP3K7KDRCDC7PLK4 | |
| SCHEMBL24800066 | 0.89 | IRAK4 (1.00) | IRAK4MAP3K7 | |
| SCHEMBL19754808 | 0.89 | IRAK4 (1.00) | IRAK4MAP3K7 | |
| SCHEMBL22452923 | 0.89 | IRAK4 (1.00) | IRAK4MAP3K7 | |
| SCHEMBL1305489 | 0.84 | IRAK4 (0.72) | IRAK4MAP3K7KDRCDC7PLK4 | |
| SCHEMBL19742913 | 0.79 | IRAK4 (1.00) | IRAK4MAP3K7 | |
| SCHEMBL22452428 | 0.79 | IRAK4 (1.00) | IRAK4MAP3K7 | |
| SCHEMBL24799802 | 0.79 | IRAK4 (1.00) | IRAK4MAP3K7 | |
| SCHEMBL30044995 | 0.79 | IRAK4 (1.00) | IRAK4MAP3K7 | |
| SCHEMBL12565141 | 0.77 | IRAK4 (0.72) | IRAK4MAP3K7KDRCDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230095835-A1 | 2,4-DIAMINO-PYRIMIDINE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-03-30 | — | — | US | disclosed |
| US-11524955-B2 | 2,4-diamino-pyrimidine compounds and method for making and using the compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2022-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230095835-A1 | 2,4-DIAMINO-PYRIMIDINE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS | IRAK4, IRAK1, IRAK3 | IRAK4 1/4885MAP3K7 30/4885KDR 2620/4885 |
| US-11524955-B2 | 2,4-diamino-pyrimidine compounds and method for making and using the compounds | IRAK4, IRAK1, IRAK3 | IRAK4 1/4885MAP3K7 30/4885KDR 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.