Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.50 |
| ▸ | INSR | P06213 | 3/20 | 0.50 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886687 | 0.83 | ALK (0.53) | ALKINSRMAP4K1METLRRK2 | |
| SCHEMBL886686 | 0.75 | ALK (0.75) | ALKINSRMAP4K1METLRRK2 | |
| SCHEMBL886362 | 0.74 | ALK (0.69) | ALKINSRMAP4K1METLRRK2 | |
| SCHEMBL2062725 | 0.73 | LRRK2 (0.59) | ALKINSRLRRK2 | |
| SCHEMBL3015152 | 0.73 | ALK (0.57) | ALKINSRMAP4K1METLRRK2 | |
| SCHEMBL886756 | 0.72 | ALK (0.71) | ALKINSRMAP4K1METLRRK2 | |
| SCHEMBL886668 | 0.72 | ALK (0.69) | ALKINSRMAP4K1MET | |
| SCHEMBL886638 | 0.71 | ALK (0.91) | ALKINSRMAP4K1METLRRK2 | |
| SCHEMBL886482 | 0.68 | MAP4K1 (0.59) | ALKINSRMAP4K1METLRRK2 | |
| SCHEMBL885933 | 0.68 | ALK (0.78) | ALKINSRMAP4K1METLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |