Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | CBL | P22681 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24821840 | 1.00 | CBLB (0.37) | CBLBPIM1SCN9AHSD11B1PTGES | |
| SCHEMBL24820229 | 0.89 | CBLB (0.43) | CBLBPIM1SCN9AHSD11B1CBL | |
| SCHEMBL30153188 | 0.89 | CBLB (0.43) | CBLBPIM1SCN9AHSD11B1CBL | |
| SCHEMBL30152984 | 0.86 | CBLB (0.37) | CBLBPIM1SCN9AHSD11B1CBL | |
| SCHEMBL24821839 | 0.86 | CBLB (0.37) | CBLBPIM1SCN9AHSD11B1CBL | |
| SCHEMBL24820285 | 0.86 | SCN9A (0.38) | CBLBSCN9AHSD11B1CBLPIN1 | |
| SCHEMBL30152588 | 0.86 | SCN9A (0.38) | CBLBSCN9AHSD11B1CBLPIN1 | |
| SCHEMBL24819888 | 0.83 | PIM1 (0.36) | CBLBPIM1SCN9AHSD11B1CBL | |
| SCHEMBL30152668 | 0.83 | PIM1 (0.36) | CBLBPIM1SCN9AHSD11B1CBL | |
| SCHEMBL24818853 | 0.80 | SCD (0.35) | CBLBPIM1SCN9AHSD11B1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |