Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | RXRG | P48443 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8642403 | 0.86 | CA14 (0.46) | CA14CA12CA1CA9MMP1 | |
| SCHEMBL8642397 | 0.86 | CA14 (0.46) | CA14CA12CA1CA9MMP1 | |
| SCHEMBL3019714 | 0.84 | CA14 (0.43) | CA14CA12CA1CA9MMP1 | |
| SCHEMBL14617832 | 0.82 | CA14 (0.34) | CA14HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL8641770 | 0.82 | CA14 (0.43) | CA14CA12CA1CA9MMP1 | |
| SCHEMBL8641767 | 0.82 | CA14 (0.43) | CA14CA12CA1CA9MMP1 | |
| SCHEMBL25969918 | 0.81 | CA14 (0.54) | CA14CA12CA1CA9MMP1 | |
| SCHEMBL8640041 | 0.80 | CA14 (0.46) | CA14CA12CA1CA9HDAC6 | |
| SCHEMBL8640034 | 0.80 | CA14 (0.46) | CA14CA12CA1CA9HDAC6 | |
| SCHEMBL15801155 | 0.79 | CA14 (0.44) | CA14ZDHHC20CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373825-A1 | NITRILE SUMO INHIBITORS AND USES THEREOF | Suvalent Therapeutics, Inc. (US) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023004376-A1 | NITRILE SUMO INHIBITORS AND USES THEREOF | Suvalent Therapeutics, Inc. (US) | 2023-01-26 | — | — | WO | disclosed |