Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 7/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21072543 | 1.00 | PARP1 (0.42) | PARP1PARP2CA1CA2KDM4E | |
| SCHEMBL6928926 | 0.79 | PARP1 (0.62) | PARP1PARP2KDM4ERECQLPARP14 | |
| SCHEMBL20404208 | 0.78 | PARP1 (0.64) | PARP1CA1CA2KDM4ETNKS2 | |
| SCHEMBL6931061 | 0.78 | PARP1 (0.47) | PARP1PARP2KDM4ERECQLPARP14 | |
| SCHEMBL6929158 | 0.78 | PARP1 (0.64) | PARP1PARP2PARP14PARP11TNKS2 | |
| SCHEMBL31483817 | 0.78 | PARP1 (0.64) | PARP1PARP2PARP14PARP11TNKS2 | |
| SCHEMBL30186048 | 0.74 | TNKS (0.59) | PARP1PARP2KDM4EPARP14TNKS2 | |
| SCHEMBL6930649 | 0.74 | TNKS (0.59) | PARP1PARP2KDM4EPARP14TNKS2 | |
| SCHEMBL29443262 | 0.74 | PARP14 (0.72) | PARP14 | |
| SCHEMBL6922477 | 0.74 | GAA (0.35) | PARP1PARP2KDM4EPARP14TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111699176-B | Quinazolinones as PARP14 inhibitors | 里邦医疗公司 | 2025-02-14 | — | — | CN | disclosed |
| EP-4212515-A1 | QUINAZOLINONES AS PARP14 INHIBITORS | Ribon Therapeutics Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| EP-3728207-B1 | QUINAZOLINONES AS PARP14 INHIBITORS | RIBON THERAPEUTICS INC (US) | 2023-02-01 | — | — | EP | disclosed |