Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.64 |
| ▸ | WIZ | O95785 | 1/20 | 0.57 |
| ▸ | IKZF2 | Q9UKS7 | 8/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30160840 | 0.97 | CRBN (0.62) | CRBNWIZIKZF2CSNK1A1IKZF1 | |
| SCHEMBL29158021 | 0.93 | CRBN (0.69) | CRBNWIZIKZF2CSNK1A1 | |
| SCHEMBL24207034 | 0.93 | CRBN (0.69) | CRBNWIZIKZF2CSNK1A1 | |
| SCHEMBL30903865 | 0.93 | CRBN (0.69) | CRBNWIZIKZF2CSNK1A1 | |
| SCHEMBL30161002 | 0.93 | CRBN (0.62) | CRBNWIZIKZF2 | |
| SCHEMBL30903866 | 0.92 | CRBN (0.67) | CRBNWIZIKZF2CSNK1A1 | |
| SCHEMBL20231556 | 0.89 | CRBN (0.67) | CRBNWIZIKZF2CSNK1A1IKZF1 | |
| SCHEMBL29482861 | 0.89 | CRBN (0.66) | CRBNWIZIKZF2CSNK1A1IKZF1 | |
| SCHEMBL24319207 | 0.89 | CRBN (0.66) | CRBNWIZIKZF2CSNK1A1IKZF1 | |
| Hydrochloric Acid SCHEMBL31205353 | 0.88 | CRBN (0.65) | CRBNWIZIKZF2CSNK1A1IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023274390-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2023-01-05 | — | — | WO | disclosed |