Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ticarcillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.86 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 5/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.63 |
| ▸ | RECQL | P46063 | 4/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | FPR1 | P21462 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TEK | Q02763 | 1/20 | 0.51 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ticarcillin SCHEMBL11113899 | 0.99 | SMN1; SMN2 (0.87) | SMN1; SMN2PTGS1LMNAKDM4ERECQL | |
| Ticarcillin SCHEMBL18048101 | 0.94 | SMN1; SMN2 (0.88) | SMN1; SMN2PTGS1LMNAKDM4ERECQL | |
| Ticarcillin SCHEMBL41223 | 0.92 | SMN1; SMN2 (1.00) | SMN1; SMN2PTGS1LMNAKDM4ERECQL | |
| Ticarcillin SCHEMBL41224 | 0.92 | SMN1; SMN2 (1.00) | SMN1; SMN2PTGS1LMNAKDM4ERECQL | |
| Ticarcillin SCHEMBL4935403 | 0.92 | SMN1; SMN2 (1.00) | SMN1; SMN2PTGS1LMNAKDM4ERECQL | |
| Ticarcillin SCHEMBL10738085 | 0.90 | PTGS1 (1.00) | SMN1; SMN2PTGS1LMNAKDM4ERECQL | |
| Ticarcillin SCHEMBL10738099 | 0.90 | PTGS1 (1.00) | SMN1; SMN2PTGS1LMNAKDM4ERECQL | |
| Ticarcillin SCHEMBL34025 | 0.90 | PTGS1 (1.00) | SMN1; SMN2PTGS1LMNAKDM4ERECQL | |
| Ticarcillin SCHEMBL5047437 | 0.90 | PTGS1 (1.00) | SMN1; SMN2PTGS1LMNAKDM4ERECQL | |
| Ticarcillin SCHEMBL4228859 | 0.89 | PTGS1 (0.98) | SMN1; SMN2PTGS1LMNAKDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110330-A1 | ANTI-VIRAL COMPOUNDS AND METHODS FOR ADMINISTRATION THEREOF | Gregg, John Malcolm Hall (US) | 2023-01-04 | — | — | EP | disclosed |