Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 17/20 | 0.75 |
| ▸ | JAK2 | O60674 | 4/20 | 0.75 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.71 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | FGR | P09769 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | SIK1 | P57059 | 1/20 | 0.51 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | ITK | Q08881 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.51 |
| ▸ | WNK3 | Q9BYP7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3775158 | 0.85 | NTRK1 (1.00) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL25567185 | 0.79 | NTRK1 (0.81) | NTRK1JAK2ALKJAK3PTK2 | |
| SCHEMBL25566031 | 0.78 | NTRK1 (1.00) | NTRK1JAK2ALKJAK3PTK2 | |
| SCHEMBL25567160 | 0.77 | NTRK1 (0.88) | NTRK1JAK2ALKJAK3PTK2 | |
| SCHEMBL3772190 | 0.76 | NTRK1 (1.00) | NTRK1JAK2ALKJAK3ABL1 | |
| SCHEMBL25565953 | 0.75 | NTRK1 (1.00) | NTRK1JAK2ALKJAK3PTK2 | |
| SCHEMBL3766966 | 0.74 | NTRK1 (1.00) | NTRK1JAK2ALKJAK3ABL1 | |
| SCHEMBL25567115 | 0.74 | NTRK1 (0.85) | NTRK1JAK2ALKPTK2 | |
| SCHEMBL25575340 | 0.74 | NTRK1 (0.81) | NTRK1JAK2ALKPTK2 | |
| SCHEMBL3773405 | 0.73 | NTRK1 (1.00) | NTRK1JAK2ALKJAK3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110340-A1 | POTENT AND SELECTIVE DEGRADERS OF ALK | Dana-Farber Cancer Institute, Inc. (US) | 2023-01-04 | — | — | EP | claimed |
| EP-4110340-A1 | POTENT AND SELECTIVE DEGRADERS OF ALK | Dana-Farber Cancer Institute, Inc. (US) | 2023-01-04 | — | — | EP | disclosed |