Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | CAMK1D | Q8IU85 | 5/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30160748 | 0.89 | JAK3 (0.44) | JAK3CAMK1DGRM5LCKBTK | |
| SCHEMBL30160804 | 0.86 | JAK3 (0.40) | JAK3CAMK1DGRM5LCKBTK | |
| SCHEMBL30165869 | 0.85 | SCN9A (0.47) | JAK3LCKBTKSCN9A | |
| SCHEMBL30160681 | 0.78 | JAK3 (0.52) | JAK3LCKBTK | |
| SCHEMBL30160759 | 0.78 | JAK3 (0.52) | JAK3LCKBTK | |
| SCHEMBL30165833 | 0.78 | BTK (0.38) | JAK3CAMK1DLCKBTK | |
| SCHEMBL30165816 | 0.77 | JAK3 (0.42) | JAK3LCKBTK | |
| SCHEMBL30165878 | 0.77 | BTK (0.41) | JAK3CAMK1DLCKBTK | |
| SCHEMBL30160951 | 0.76 | JAK3 (0.40) | JAK3CAMK1DLCKBTK | |
| SCHEMBL30165804 | 0.76 | JAK3 (0.49) | JAK3LCKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557933-B | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-115557933-A | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-01-03 | — | — | CN | disclosed |