Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 3/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 4/20 | 0.44 |
| ▸ | FYN | P06241 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24105025 | 1.00 | PTK6 (0.49) | PTK6TNIKTTKFYNPIK3CA | |
| SCHEMBL24104678 | 0.91 | TTK (0.44) | PTK6TNIKTTKFYNEGFR | |
| SCHEMBL30168196 | 0.91 | TTK (0.44) | PTK6TNIKTTKFYNEGFR | |
| SCHEMBL30168157 | 0.89 | PTK6 (0.49) | PTK6TTKFYNPIK3CAEGFR | |
| SCHEMBL24104766 | 0.89 | TTK (0.45) | PTK6TNIKTTKFYNMAPKAPK5 | |
| SCHEMBL30168129 | 0.89 | TTK (0.45) | PTK6TNIKTTKFYNMAPKAPK5 | |
| SCHEMBL24105229 | 0.89 | PTK6 (0.49) | PTK6TTKFYNPIK3CAEGFR | |
| SCHEMBL24105199 | 0.89 | TTK (0.45) | PTK6TNIKTTKFYNMAPKAPK5 | |
| SCHEMBL24105022 | 0.88 | TTK (0.52) | TTKMAPKAPK5AURKA | |
| SCHEMBL24105249 | 0.85 | PTK6 (0.48) | PTK6TTKMAPKAPK5AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667264-A | Novel imidazo-pyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | claimed |
| CN-115667264-A | Novel imidazo-pyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |