Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11207376 | 0.76 | HPGD (0.55) | MCL1HSD17B10USP2HPGDALDH1A1 | |
| SCHEMBL17520237 | 0.71 | HSD17B10 (0.57) | MCL1HSD17B10USP2HPGDALDH1A1 | |
| SCHEMBL29476290 | 0.71 | MCL1 (0.41) | MCL1KMT2ABCL2HTR2AHTR2C | |
| SCHEMBL29476202 | 0.71 | MCL1 (0.52) | MCL1ALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL9811408 | 0.70 | MCL1 (0.60) | MCL1HSD17B10USP2HPGDALDH1A1 | |
| SCHEMBL12000241 | 0.69 | MCL1 (0.55) | MCL1HSD17B10USP2HPGDALDH1A1 | |
| SCHEMBL15181677 | 0.69 | MCL1 (0.55) | MCL1HSD17B10USP2HPGDALDH1A1 | |
| SCHEMBL9078237 | 0.68 | NPC1 (0.56) | MCL1HSD17B10USP2HPGDALDH1A1 | |
| SCHEMBL12168237 | 0.68 | MCL1 (0.68) | MCL1HSD17B10USP2HPGDALDH1A1 | |
| SCHEMBL31192194 | 0.68 | MCL1 (0.53) | MCL1HSD17B10USP2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266069-A1 | TRICYCLIC KRAS G12D INHIBITORS | ERASCA, INC. (US) | 2022-12-22 | — | — | WO | disclosed |